Xgeva 120mg Injection (Denosumab)
Xgeva 120mg Injection contains denosumab, a monoclonal antibody used in cancer care to protect the bones. It works by blocking a protein (RANK ligand) that activates the cells that break down bone. By reducing this bone breakdown, it helps prevent the bone damage and complications that some cancers cause. Xgeva uses include preventing bone complications (such as fractures and bone pain needing radiotherapy) in adults with cancer that has spread to the bone, and treating a bone tumour called giant cell tumour of bone. It is given as an injection under the skin under specialist supervision.
Description
Xgeva 120mg Injection Uses
- Prevents bone complications in adults with cancer that has spread to the bone
- Helps reduce the risk of fractures, bone pain, and the need for bone radiotherapy or surgery
- Treats giant cell tumour of bone that cannot be removed by surgery, or where surgery would cause severe harm
- Treats high blood calcium caused by cancer when other treatment has not worked
- Prescribed by a specialist as part of a cancer treatment plan
How Xgeva Is Given
Xgeva is given as an injection under the skin (in the upper arm, thigh, or abdomen) by a doctor or nurse, usually once every four weeks for bone protection in cancer. Calcium and vitamin D are taken alongside it unless your blood calcium is already high. The dose and schedule are set by your specialist. It is important to receive doses on time and to attend monitoring appointments. Never adjust or stop treatment without medical advice.
Xgeva 120mg Injection Warnings
- Can cause low calcium levels in the blood, which can be serious; calcium is corrected before starting, and calcium and vitamin D are taken during treatment
- Risk of serious jaw bone problems (osteonecrosis of the jaw), especially after dental surgery or with poor dental health
- Rare risk of unusual thigh bone fractures
- After stopping, there can be a risk of multiple spine fractures in some patients
- Can harm an unborn baby; effective contraception is required during and after treatment
- Tell your doctor about any dental problems or planned dental work before starting
Xgeva 120mg Injection Precautions
- Used only under the supervision of a specialist
- Blood calcium is monitored, and calcium and vitamin D are taken as advised
- Have a dental check-up before starting if advised, and maintain good dental hygiene
- Tell your doctor before any dental surgery that you are receiving this medicine
- Report any jaw pain, loose teeth, non-healing mouth sores, or new thigh or groin pain promptly
- Report symptoms of low calcium, such as muscle cramps, numbness, or tingling
- Tell your doctor about any kidney problems and all other medicines you take
Xgeva 120mg Injection Side Effects
- Low calcium levels
- Bone, joint, or muscle pain
- Tiredness and weakness
- Nausea and diarrhoea
- Shortness of breath
- Jaw bone problems (less common but serious)
- Serious effects, such as symptoms of low calcium, jaw pain or non-healing mouth sores, or unusual thigh pain, need medical attention
Storage Instructions
- Store in a refrigerator between 2°C and 8°C
- Do not freeze
- Keep in the original carton to protect from light
- May be kept at room temperature for a limited period before use if advised, then used within the stated time
- Handled and stored by the pharmacy cold chain; keep out of the reach of children
Packaging and Quantity
Available as a single vial containing denosumab 120mg.
Prescription Requirement
Xgeva is a specialist prescription-only medicine, given by a healthcare professional. It is supplied against a valid prescription and administered under medical supervision. It cannot be dispensed for unsupervised self-use.
Frequently Asked Questions about Xgeva 120mg Injection
What is the price of Xgeva 120mg Injection in Pakistan?
The price of Xgeva 120mg Injection in Pakistan varies as it is an imported specialist medicine. At Delta Pharmacy it is supplied only against a valid prescription and under proper cold-chain handling.
Is Xgeva 120mg Injection available in Pakistan?
Yes, Xgeva 120mg Injection is available in Pakistan through specialist pharmacy supply, dispensed against a prescription and kept under cold-chain storage.
What is Xgeva 120mg Injection used for?
It is used to prevent bone complications in cancer that has spread to the bone, and to treat giant cell tumour of bone, by reducing bone breakdown.
What is the difference between Xgeva and Prolia?
Both contain denosumab, but Xgeva is the higher-dose form used in cancer-related bone care, usually every four weeks, while Prolia is the lower dose used for osteoporosis every six months. They are not interchangeable.
Disclaimer
This information is provided by Delta Pharmacy for general awareness only and is not a substitute for professional medical advice. Xgeva (denosumab) is a specialist medicine given under medical supervision. Always consult your doctor about your treatment, dosage, and any health concerns before using this medicine.















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